Oral Vitamin C Supplementation and its Impact on Endothelial Function in Obstructive Sleep Apnea Patients

Authors

  • Zakaria A Alyousif University of Toledo
  • Craig P Black
  • Suzanne Wambold
  • Sadik A. Khuder
  • Barry W Scheuermann

Abstract

Background Obstructive Sleep Apnea (OSA) is a prevalent condition associated with endothelial dysfunction, a precursor to cardiovascular disease. Passive Leg Movement (PLM) has emerged as a simple method to assess endothelial function. The role of oral vitamin C in improving endothelial function in OSA patients, however, has been underexplored.

 

Materials and Methods

This study recruited 26 male subjects, 13 with OSA and 13 healthy controls, aged 18-55 years. PLM was utilized to assess endothelial function by measuring femoral artery blood flow (FBF) and velocity (FBV) using Doppler ultrasound, pre- and post-administration of 1000mg of oral vitamin C. The intervention aimed to compare endothelial function responses between OSA patients and healthy controls, and to evaluate the impact of oral vitamin C on these responses.

Results

Baseline comparisons revealed a significant difference in FBF between OSA patients (76.6 ml/min) and healthy controls (162.1 ml/min, p < 0.05), indicating endothelial dysfunction in OSA. Post-vitamin C intervention, the peak FBF responses in OSA patients showed no significant difference (Pre-vitamin C: 76.6 ml/min, Post-vitamin C: 79.9 ml/min, p > 0.05), suggesting that oral vitamin C did not significantly improve endothelial function in OSA patients.

Conclusion

PLM effectively distinguished between healthy subjects and those with OSA through differences in FBF, confirming its utility as a diagnostic tool for endothelial dysfunction. However, oral vitamin C supplementation did not significantly enhance endothelial function in OSA patients, indicating the need for further research into alternative or adjunctive therapies.

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Published

2024-03-10

How to Cite

Alyousif, Z. A., Black, C. P., Wambold, S., Khuder, S. A., & Scheuermann, B. W. (2024). Oral Vitamin C Supplementation and its Impact on Endothelial Function in Obstructive Sleep Apnea Patients. Journal of Advanced Sciences, 3(1). Retrieved from https://www.joasciences.com/index.php/joas/article/view/47